Pancreatic Cancer News

December 5, 2023

Top Headlines

Stimulating Nerves Connected to the Pancreas Regenerates Insulin-Producing Cells, Mouse Study Shows

Dec. 4, 2023 — Decreasing pancreatic beta cell numbers -- the only cells that produce insulin -- is a leading cause of diabetes. In a promising development, a research group has revealed that stimulating autonomic ...

Can We Crack This Cancer's Immune Response?

Nov. 29, 2023 — Researchers have discovered antibodies that interact with pancreatic cancer cells and healthy cells. These findings contribute to our knowledge of how the disease works. And they could help pinpoint future efforts for developing immunotherapy ...

Novel Molecular Mechanisms in the Early Development of Diabetes Mellitus

Nov. 21, 2023 — Researchers conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Analysis results revealed upregulation of Anxa10 expression in pancreatic beta cells during the early phases ...

Pancreatic Cancer Discovery Opens the Door for New Clinical Trial

Nov. 16, 2023 — A new scientific finding is the foundation for the first clinical trial in the U.S. to study an experimental drug's ability to fight pancreatic cancer with metastasis to the liver. ...

Latest Headlines

updated 10:57pm EST

Macrophages 'Eat' Insulin-Producing Cells to Regulate Insulin After Mice Have Given Birth

Dec. 4, 2023 — Pregnancy brings a rise in pancreatic beta cells -- the cells that produce insulin. Shortly after birth, these cells return to their normal levels. ...

Nanoparticles for Optimized Cancer Therapy

Nov. 15, 2023 — Pancreatic cancer is one of the deadliest types of cancers in humans. It is the fourth leading cause of cancer-related deaths in the western world. The early stages of the disease often progress ...

Drug Screen Points Toward Novel Diabetes Treatments

Nov. 9, 2023 — A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 ...

A Step Closer to Injection-Free Diabetes Care: Innovation in Insulin-Producing Cells

Nov. 6, 2023 — A team has developed a new step to improve the process for creating insulin-producing pancreatic cells from a patient's own stem cells, bringing the ...

High Insulin Levels Directly Linked to Pancreatic Cancer

Oct. 31, 2023 — The first detailed explanation of why people with obesity and Type 2 diabetes are at an increased risk of pancreatic cancer has been published. The research demonstrates that excessive insulin levels ...

New Study Suggests Promising Approach for Treating Pancreatic Cancer

Oct. 18, 2023 — A new study carried out in mice, has identified cells that drive the spread of pancreatic cancer and discovered a weakness in these cells that could be targeted using existing drugs. This offers a ...

A Powerful New Tool in the Fight Against One of the Deadliest Cancers

Oct. 16, 2023 — A research team has developed a theranostics approach to both diagnose and treat certain pancreatic cancer cases. They radioactively labeled a monoclonal antibody targeting glypican-1, which is ...

Can Immunity from Routine Vaccines Be Used to Fight Cancer?

Oct. 10, 2023 — A team has demonstrated in theory that a protein antigen from a childhood vaccine can be delivered into the cells of a malignant tumor to refocus the body's immune system against the cancer, ...

Newfound Mechanism Suggests Drug Combination Could Starve Pancreatic Cancer

Oct. 9, 2023 — A study found that a new combination of treatments safely decreased growth of pancreatic cancer in mice by preventing cancer cells from scavenging for ...

'Super-Enhancer' Super-Charges Pancreatic Tumor Growth

Sep. 6, 2023 — Scientists identified new set of molecules that drive the growth of human pancreatic cancer cell lines, explaining how genetic mutations can activate genetic 'super-enhancers' that promote ...

Earlier Headlines

Summaries
Headlines

Drug That Targets Scar-Like Tissue in Tumors Shows Promise for Aggressive Pancreatic Cancer

Aug. 29, 2023 — Early laboratory results in mice show the drug PXS-5505 increases survival when combined with chemotherapy in the treatment of pancreatic ductal ...

Enhanced Tumor Modeling Using Laponite Bioinks for 3D Bioprinting

Aug. 3, 2023 — Scientists have developed a nanoengineered bioink with improved bonding and cross-linking capabilities for 3D bioprinted tumor models. These capabilities are enabled by the addition of Laponite, ...

New Research Casts Doubt on Role of Fungus in Driving Pancreatic Cancer

Aug. 3, 2023 — Four years ago, a report that a common species of fungus might fuel pancreatic cancer offered a promising new view of the deadly disease. But in working to validate the finding, researchers have ...

Pancreatic Cancer Vaccine Plus Immunotherapy and Antibody Spark Immune System Response in Pancreatic Cancers

July 17, 2023 — Giving patients with operable pancreatic cancers a three-pronged combination immunotherapy treatment consisting of the pancreatic cancer vaccine GVAX, the immune checkpoint therapy nivolumab and ...

One-Two Punch: Novel Drug Pairing Could Beat Pancreatic Cancer

June 28, 2023 — Researchers find a combination of drugs outperformed other treatments in human and mouse models of pancreatic cancer; now urge clinical ...

Cancer Cells Use a New Fuel in Absence of Sugar

May 18, 2023 — Researchers have discovered a new nutrient source that pancreatic cancer cells use to grow. The molecule, uridine, offers insight into both biochemical processes and possible therapeutic pathways. ...

Implantable Device Shrinks Pancreatic Tumors

Apr. 13, 2023 — Nanomedicine researchers have found a way to tame pancreatic cancer -- one of the most aggressive and difficult to treat cancers -- by delivering immunotherapy directly into the tumor with a device ...

Biomarkers Show Promise for Identifying Early Risk of Pancreatic Cancer

Mar. 17, 2023 — A research team has identified a set of biomarkers that could help distinguish whether cysts on the pancreas are likely to develop into cancer or remain ...

How Pancreatic Cancer Defies Treatment

Jan. 19, 2023 — Researchers describe how pancreatic cancer stem cells leverage a protein in a family of proteins that normally suppress tumors to instead do the opposite, boosting their resistance to conventional ...

Stress-Tolerant Cells Drive Tumor Initiation in Pancreatic Cancer

Jan. 16, 2023 — Scientists discover a molecular pathway critical to the initiation of pancreatic tumors. The findings may inspire new chemotherapeutic drugs targeting early stages of tumor formation and ...

Study Discovers Triple Immunotherapy Combination as Possible Treatment for Pancreatic Cancer

Dec. 30, 2022 — Researchers have discovered a novel immunotherapy combination, targeting checkpoints in both T cells and myeloid suppressor cells, that successfully reprogrammed the tumor immune microenvironment ...

Adjuvant Chemotherapy Improves Overall Survival for Pancreatic Cancer Patients

Dec. 8, 2022 — A new study showcases chemotherapy treatment before and after surgery for pancreatic cancer as the most effective combination for ...

Study Shows Promise of New Anti-KRAS Drug for Pancreatic Cancer

Dec. 6, 2022 — A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth ...

New Genetic Culprit Suspected in the Onset of Pancreatic Cancer

Nov. 30, 2022 — New research points to the inactivation of a previously unidentified gene as a likely culprit in the development of pancreatic cancer. The findings could alter the scientific understanding of this ...

New Insights Into the Mechanisms Causing Diabetes

Nov. 7, 2022 — Researchers show that a molecule called T-cadherin can be secreted in a soluble form. Soluble T-cadherin interacts with pancreatic insulin-producing beta cells via the Notch signaling pathway to ...

Cancer Deaths Continue Downward Trend in U.S.; Modest Improvements in Survival for Pancreatic Cancer

Oct. 27, 2022 — Overall cancer death rates continued to decline among men, women, children, and adolescents and young adults in every major racial and ethnic group in the United States from 2015 to 2019, according ...

Gel-Like, Radioactive Tumor Implant Obliterates Pancreatic Cancer in Mice

Oct. 20, 2022 — Biomedical engineers have demonstrated the most effective treatment for pancreatic cancer in mouse models ever recorded. While most mouse trials consider simply halting growth a success, the new ...

Two Drugs Reverse Key Pancreatic Cancer Step in the Lab

Oct. 19, 2022 — Two drugs -- one brand new -- reverse pancreatic cell changes that presage one of the hardest cancers to treat. Tested in cells, the drugs would be a promising early cancer treatment if they work in ...

Scientists Identify Link Between Mitochondria and Pancreatic Cancer Risk

Oct. 12, 2022 — Scientists distinguish a specific gene signature indicative of mitochondrial reprogramming in tumors that correlates with poor patient ...

Researchers Find Tumor Microbiome Interactions May Identify New Approaches for Pancreatic Cancer Treatment

Oct. 10, 2022 — Investigators have examined the microbiome of pancreatic tumors and identified particular microorganisms at single cell resolution that are associated with inflammation and with poor survival. ...

Tuesday, August 29, 2023